Keeping My Mom Off the Pole

29 May 2018 / Ryan Beal / No Comments

My mom’s never wanted to be on the pole. Unfortunately, there could come a time when she has no choice. I hope to change that.

About 3 years ago, I put a needle in my arm. Deep. Straight down. The needle was an 18-gauge needle (about the size of the tip of a ball point pen). I put it over an inch deep, straight into my forearm. I didn’t feel a thing. I was testing an early version of our technology coupled with lidocaine. We had achieved needle-like delivery of a numbing agent that had completely numbed me within minutes. It was my proverbial stake in the ground: we could replace needles.

Over the past 3 years we’ve assembled a range of data. Bioavailability, pharmacokinetic, histologic, visual, and market data. We’re still in the early stages, and we have much more to prove, but Dyve’s technology has shown that it can deliver. We’re showing bioavailability data that surpasses oral delivery and pharmacokinetic data that makes IV delivery look outdated.

While our technology is behind some cool products that are on market, you’re in for a big surprise as our pipeline matures. We’ll be introducing step-changes in efficacy in some key aesthetic markets. What I find most inspiring though is that in our pursuit of aesthetic innovation, we’ve discovered something uniquely beautiful: using the skin as a bioavailability portal. That opens up a range of medical therapeutics and disease states. We’ll be making the jump from age spots, crow’s feet, and flank fat to oncology, Alzheimer’s, and arteriosclerosis.

If we’re successful in turning the skin into a bioavailability portal, we’ll be able to fundamentally change how scientists think about what is possible. We believe we can essentially take a molecule’s half-life, solubility, and size off the table. Worried about gut acidity and first-pass metabolism? We’re not. Think a needle or IV drip may be required? We don’t.

There are many things that motivate me about what we’re doing at Dyve. The team that I get to work with every day. The creative approaches we’re taking to solving some cool biophysical challenges. The impact we expect to have clinically and commercially. But one of the coolest things to ponder is the idea that, based on what we’re seeing, we think it’s possible to do away with the IV bag. Your forearm could be its own IV bag.

And if you don’t need the IV bag, there’s no need for the pole that carries it around.

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